DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI
Authors' conclusion
CB DNAm at birth may partially mediate effects of prePregBMI on early childhood BMIz36, supporting its plausible role in influencing individual future obesity risk.
Study context
- Population
- Mother-child pairs of women with obesity, Treatment of Obese Pregnant Women (TOP) study
- Participants
- 232 mother-child pairs
- Outcome
- Association of prePregBMI with cord blood DNA methylation, and mediation by DNAm of the effect of prePregBMI on BMIz
- Follow-up
- BMIz at age 36 months
Methodological detailsepigenome-wide association study (450k array), causal mediation analysis, cross-validation
- Epigenome-wide association study (450k array)
- Causal mediation analysis
- Cross-validation
Main finding
As reported in the abstract
- CpG sites with DNA methylation (DNAm) associated with prePregBMI (FDR < 10%), annotated to 2842 genes overrepresented in carbohydrate metabolism and plasma lipoprotein particle clearance
- 5345
- Methylation sites associated with BMIz36 (p < 0.05) and overlapping prePregBMI-associated sites, tested for mediation
- 168
- Sites on SYT7 and DEAF1 partially mediating the effect of prePregBMI on BMIz36
- p ≤ 0.01
Observational data: associations, not effects.
Further findings
Methylation risk score (SYT7 and DEAF1 sites) predicting highest quartile of BMIz36 · 36 months
- AUC
- 0.72 (95% CI: 0.58-0.85)
- After cross-validation
Methylation risk score predicting highest quartile of fat mass (g)
- AUC
- 0.71 (95% CI: 0.58-0.85)
- After cross-validation
Original publication
DNA methylation in cord blood partially mediates the effects of prepregnancy BMI on early childhood offspring BMI. Obesity (Silver Spring). Published 11 December 2024. doi:10.
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