The associations among maternal gestational weight gain, cord blood DNA methylation, and offspring childhood high BMI
Authors' conclusion
Maternal GWG and childhood BMI status at age 3 years were associated with newborn cord blood DNA methylation.
Study context
- Population
- Newborns' cord blood samples; offspring BMI status at 3 years
- Participants
- 40 cord blood samples
- Outcome
- GWG-related cord blood DNA methylation and childhood BMI at 3 years
- Follow-up
- Age 3 years
Methodological detailsepigenome-wide (Illumina Infinium MethylationEPIC Bead Chip), external validation, mediation analysis
- Epigenome-wide (Illumina Infinium MethylationEPIC Bead Chip)
- External validation
- Mediation analysis
Main finding
As reported in the abstract
age 3 years
Gestational weight gain (GWG)-related differential methylation probes in cord blood
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Sites associated with children's BMI at age 3 years: cg09973771 (SNTG2), cg00254258 (PRDM16), cg02672830 (MCPH1), cg15424377
4
Observational data: associations, not effects.
Further findings
Mediation by cord blood DNA methylation of GWG–high BMI association
- Mediating effect not detected
External validation in peripheral blood · age 3 years
- cg09973771 (SNTG2) methylation showed nominal significant differences among children with different BMI statuses
Original publication
The associations among maternal gestational weight gain, cord blood DNA methylation, and offspring childhood high BMI. Obesity (Silver Spring). Published 19 March 2025. doi:10.
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