Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity
Authors' conclusion
DNA methylation may play a role in the association of maternal triglycerides and child adiposity.
Study context
- Population
- Pregnant women (27–34 weeks' gestation) with fasting serum insulin, glucose, HDL-C, TG and free fatty acids; offspring cord blood DNA methylation and child adiposity at birth, 4–6 months and 4–6 years
- Participants
- 588 pregnant women
- Outcome
- Association of maternal metabolic traits with cord blood DNA methylation (429,246 CpGs)
Methodological detailsepigenome-wide association study, mediation analysis
- Epigenome-wide association study
- Mediation analysis
Main finding
As reported in the abstract
Maternal TG associated differentially methylated probes (DMPs) (most of all traits tested; false discovery rate < 0.05)
261
Maternal TG associated DMRs (most of all traits tested; false discovery rate < 0.05)
198
Observational data: associations, not effects.
Further findings
TG-associated CpGs associated with child adiposity
- CpGs associated with child adiposity at 4-6 months
- 32 CpGs
- CpGs associated with child adiposity at 4-6 years
- 2 CpGs
Mediation by CpG near CD226 (observed at both timepoints) of maternal TG–child adiposity relationship
- Proportion mediated at 4-6 months
- 10%
- Proportion mediated at 4-6 years
- 22%
Original publication
Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity. Obesity (Silver Spring). Published 23 October 2023. doi:10.
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