Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults
Authors' conclusion
Short-term estimated fracture risk at the radius following VSG decreases. However, ongoing bone loss despite stable weight between years 1 and 2 leads to a concerning rise in estimated fracture risk. Longer follow-up will be critical to evaluate the trajectory of fracture risk.
Study context
- Population
- Youth aged 13–24 years with obesity
- Participants
- 24 vs 34
- Exposure
- Vertical sleeve gastrectomy (VSG) vs lifestyle therapy
- VSGn = 24
- Lifestyle therapyn = 34reference
- Outcome
- Estimated fracture risk at the distal radius by load-to-strength ratio (LSR), from HR-pQCT and microfinite element analysis
- Follow-up
- Years 1 and 2
Methodological details2-year follow-up
- 2-year follow-up
Main finding
As reported in the abstract
LSR · year 1 and year 2
- VSG: Load-to-strength ratio (LSR) decreased at year 1, implying lower fracture risk
- p < 0.001
- VSG: LSR at year 2 lower than baseline
- p < 0.001
- VSG: LSR at year 2 higher than at year 1
- p = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | VSG | Lifestyle therapy |
|---|---|---|
| Weight change · years 1 and 2 | 26.4 ± 8.1 % weight lost at year 1 | 4.5 ± 8.3 % weight gained at year 2 |
- Weight change — VSG weight loss at year 1
- p < 0.001
- Weight change — Lifestyle therapy weight gain at year 2
- p = 0.009
Weight change · years 1 and 2
- VSG weight loss sustained at year 2
Predicted impact force · years 1 and 2
- VSG: decreased at years 1 and 2
- P < 0.001
- Lifestyle therapy: increased at year 2
- P = 0.011
Estimated bone strength · years 1 and 2
- VSG: unchanged at year 1, decreased at year 2
- P < 0.001
- Lifestyle therapy: did not change
Original publication
Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults. Osteoporos Int. Published 21 October 2023. doi:10.
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