Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes
Authors' conclusion
Reductions in BMI, lean mass, and sex steroids over 24 months post-SG are associated with bone loss and could be targeted for preventative or therapeutic interventions.
Study context
- Population
- Youth 13–25 years old with moderate-to-severe obesity
- Participants
- 23 vs 30
- Exposure
- Sleeve gastrectomy (SG) vs non-surgical controls
- SGn = 23
- NSn = 30reference
- Outcome
- Changes in BMI, bone density, bone turnover and hormones
- Follow-up
- 24 months
Methodological details24-month
- 24-month
Main finding
As reported in the abstract
- Greater reductions in BMI z-scores and spine, hip and femoral neck areal bone mineral density (aBMD) Z-scores with SG vs NS
- P ≤ .012
- Greater increases in serum CTX and sex hormone binding globulin (SHBG) with SG vs NS
- P ≤ .039
- Greater decreases in estrone and ghrelin with SG vs NS
- P ≤ .021
Observational data: associations, not effects.
Further findings
Females · 24 months
- Estrone and free androgen index decreased in SG vs NS
- P ≤ 0.022
- Decreases in estrone associated with decreases in spine aBMD Z-scores and radial total and trabecular volumetric BMD (vBMD); decrease in free androgen index (FAI) with decreases in radial failure load (adjusted for age)
Original publication
Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes. Eur J Endocrinol. Published 26 August 2023. doi:10.
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