Transitioning from having no metabolic abnormality nor obesity to metabolic impairment in a cohort of apparently healthy adults
Authors' conclusion
Roughly one-quarter of apparently healthy adults are defined as "metabolically healthy" according to current definitions. The transition from health to metabolic dysfunction is accompanied with active inflammation and several non-metabolic syndrome biomarkers. Aggressive screening for these biomarkers, blood pressure and hs-CRP might help identify apparently healthy individuals at increased risk of developing metabolic syndrome over time.
Study context
- Population
- Apparently healthy adults attending their annual health survey, Tel Aviv Sourasky Medical Center Inflammation Survey (TAMCIS)
- Participants
- 20,507 adults
- Exposure
- Metabolically healthy participants who developed metabolic impairment vs those consistently metabolically impaired
- Became metabolically impairedn = 985
- Outcome
- Prevalence of metabolically healthy individuals (no metabolic syndrome criteria nor obesity)
- Follow-up
- Baseline
Methodological detailsfollow-up visit after 4.8 (± 0.6) years
- Follow-up visit after 4.8 (± 0.6) years
Main finding
As reported in the abstract
Did not fulfill any metabolic syndrome criteria at baseline
5379 individuals
26.2%
Observational data: associations, not effects.
Further findings
Developed metabolic criteria over time · follow-up
- Developed metabolic criteria (of returning participants)
- 985 (12.7%)
- Hypertension was the most prevalent component to develop
Metabolic syndrome criteria and elevated high sensitivity C-reactive protein (hs-CRP)
- Those becoming metabolically impaired showed increased overlap between metabolic syndrome criteria and elevated hs-CRP
Delta values of biomarkers
- Higher delta WBC, RBC, liver biomarkers and uric acid in those becoming impaired vs consistently impaired
- LDL-C delta levels were similar
Original publication
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