Cardiovascular risk factors associated with body mass index (BMI) and metabolic health phenotypes based on measures of coagulation factors
Authors' conclusion
This study challenges the MUNW metric, revealing metabolic marker elevations in women without obesity. Additionally, MHO individuals exhibited pro-coagulant protein increases compared to MUO, suggesting limited clinical utility in categorizing the broader population with obesity. Our exploratory findings highlight how the interplay between metabolic health and body size phenotypes could challenge conventional frameworks for assessing health risk.
Study context
- Population
- Adult women classified by BMI and metabolic criteria
- Participants
- 225 adult women
- Exposure
- Coagulation and inflammation markers across BMI and metabolic health phenotypes (MHNW, MUNW, MHO, MUO)
- Outcome
- Hemostatic proteins and interleukins by phenotype
Main finding
As reported in the abstract
- Coagulation proteins showed normal levels
- MHNW had significantly lower FV
- Groups without obesity (MHNW and MUNW) had lower FVIII and FIX
- FXII in MHNW did not significantly differ
- IL-6 negatively correlated with PC and AT, positively with FVIII and FIX
- IL-10 negatively correlated with FII, FV, FVII, FXI and FXII
- TNF-α and IL-1 positively correlated with FVIII and FIX
Observational data: associations, not effects.
Further findings
Metabolic and anthropometric characteristics
- MHO younger, with higher visceral fat and BMI
- MUO had highest homeostatic model assessment for insulin resistance (HOMA-IR), TG and LDL-C
Original publication
Cardiovascular risk factors associated with BMI and metabolic health phenotypes based on measures of coagulation factors. Int J Obes (Lond). Published 26 September 2025. doi:10.
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