Thyroid Hormone Sensitivity as a Possible Determinant of Metabolic Phenotypes in Young Adults, Not in Older Individuals
Authors' conclusion
Our findings highlight the importance of thyroid sensitivity indices in understanding metabolic health, particularly among younger adults. Incorporating these indices into clinical assessments may enhance metabolic phenotype stratification and inform targeted management of obesity.
Study context
- Population
- Participants aged 18 years and older, National Health and Nutrition Examination Survey (NHANES) 2007 to 2012
- Exposure
- Metabolic phenotypes vs MHNW for thyroid sensitivity indices
- Outcome
- Thyroid sensitivity indices: TFQI, TSHI and Thyrotroph Thyroxine Resistance Index (TT4RI)
Methodological detailsNHANES 2007 to 2012, multivariable and piecewise regression, stratified by age (<65 and ≥65 years)
- NHANES 2007 to 2012
- Multivariable and piecewise regression
- Stratified by age (<65 and ≥65 years)
Main finding
As reported in the abstract
Thyroid sensitivity indices by metabolic phenotype
- MUO vs MHNW: P = 0.035
- MUO vs MHNW: P = 0.093
- MUO vs MHNW: P = 0.134
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Thyroid sensitivity indices, younger adults (<65 years)MUO vs MHNW · MUO showed the highest values | β TSHI 0.122 | P = 0.006 |
| Thyroid sensitivity indices, younger adults (<65 years)MUO vs MHNW | β TT4RI 2.006 | P = 0.010 |
| Thyroid sensitivity indices, younger adults (<65 years)MUO vs MHNW | β TFQI 0.058 | P = 0.018 |
- Thyroid sensitivity indices, younger adults (<65 years) — Significant linear and quadratic trends
- P < .05
Thyroid sensitivity indices, older adults (≥65 years)
- No significant associations
Original publication
Thyroid Hormone Sensitivity as a Possible Determinant of Metabolic Phenotypes in Young Adults, Not in Older Individuals. J Clin Endocrinol Metab. Published 3 April 2025. doi:10.
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