A 3-Week Ketogenic Diet Increases Global Cerebral Blood Flow and Brain-Derived Neurotrophic Factor
Authors' conclusion
Implementing a KD improved CBF and raised BDNF levels in cognitively healthy individuals, indicating that a KD should be assessed for as a potential treatment for conditions associated with reduced CBF.
Study context
- Population
- Cognitively healthy individuals with overweightcrossover
- Participants
- 11 individuals
- Comparison
- 3-week ketogenic diet vs standard diet
- Primary endpoint
- Cerebral blood flow (CBF) and brain-derived neurotrophic factor (BDNF)
- Follow-up
- End of each 3-week diet period
Methodological detailsrandomized
- Randomized
Primary result
As reported in the abstract
3 weeks
Cerebral blood flow (CBF) increase
22%
P = 0.02
Ketogenic diet (KD)
Brain-derived neurotrophic factor (BDNF) increase
47%
P = 0.04
KD
Further findings
Basal plasma β-OHB · 3 weeks · higher with KD
P < 0.05
Correlation of β-OHB with CBF across both diets
- R2
- 0.54
- P
- P < 0.001
Original publication
A 3-Week Ketogenic Diet Increases Global Cerebral Blood Flow and Brain-Derived Neurotrophic Factor. J Clin Endocrinol Metab. Published 2 April 2025. doi:10.
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