Effects of 1-Month Very-Low-Calorie Ketogenic Diet on 24-Hour Energy Metabolism and Body Composition in Women With Obesity
Authors' conclusion
VLCKD promotes weight loss in women with obesity. Our findings highlight the shift in energy metabolism towards increased FatOx accompanied by a modest increase in protein oxidation, a decrease in LST and a reduction in EE.
Study context
- Population
- Women with obesity (mean age 41.6 years; BMI 37.5 kg/m²), University Hospital of Pisa
- Participants
- 17 vs 22
- Exposure
- 1-month very-low-calorie ketogenic diet (VLCKD) vs balanced isocaloric diet
- VLCKDn = 17
- Controlsn = 22reference
- Outcome
- Energy metabolism and body composition in VLCKD
- Follow-up
- Day 29 (V3) vs day 1 (V1)
Methodological detailsmetabolic chamber, single-centre
- Metabolic chamber
- Single-centre
Main finding
As reported in the abstract
day 29 (V3) vs day 1 (V1)
- Carbohydrate oxidation (CarbOx) decrease at V3
- 65%
- Fat oxidation (FatOx) increase at V3
- 11%
- Body weight decrease after 1 month
- 7%
- Fat mass reduction
- 8.8%
- Lean soft tissue (LST) reduction
- 5.6%
- Decrease in 24hEE and 24-hour sleeping metabolic rate, V3 vs V1
- 10%
Observational data: associations, not effects.
Further findings
Substrate oxidation vs controls at V1
- CarbOx lower, FatOx and protein oxidation (ProtOx) higher in VLCKD vs controls
Original publication
Effects of 1-Month Very-Low-Calorie Ketogenic Diet on 24-Hour Energy Metabolism and Body Composition in Women With Obesity. J Clin Endocrinol Metab. Published 2 April 2025. doi:10.
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