Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes: A Randomized Clinical Trial
Authors' conclusion
This randomized clinical trial found that a TRE diet strategy without calorie counting was effective for weight loss and lowering of HbA1c levels compared with daily calorie counting in a sample of adults with T2D. These findings will need to be confirmed by larger RCTs with longer follow-up.
Study context
- Population
- Adults aged 18 to 80 years with obesity and T2D, University of Illinois Chicago; mean age 55 years, mean BMI 39, mean hemoglobin A1c (HbA1c) 8.1%, 71% womenenrolled
- Participants
- 75 adults
- Comparison
- 8-hour time-restricted eating (TRE) vs daily calorie restriction (CR) vs control
- Primary endpoint
- Change in body weight
- Follow-up
- Month 6
Methodological detailsparallel-group, 6-month
- Parallel-group
- 6-month
Primary result
As reported in the abstract
TRE
−3.56%
95% CI −5.92% to −1.20%P = 0.004
CR
−1.78%
95% CI −3.67% to 0.11%P = 0.06
Secondary outcomes
Mean, kcal/d
| Outcome | TRE | CR | Control | Estimate |
|---|---|---|---|---|
| Change in HbA1c · month 6TRE vs Control | −0.91% (95% CI −1.61% to −0.20%) | |||
| Change in HbA1c · month 6CR vs Control | −0.94% (95% CI −1.59% to −0.30%) | |||
| Reduction in energy intake | −313 (SD 509) | −197 (SD 426) | −16 (SD 439) |
Change in HbA1c · month 6
- No differences in HbA1c between TRE and CR
Adherence · over 6 months
- TRE: adherent with eating window, mean (SD) days per week
- 6.1 (0.8)
- CR: adherent with prescribed calorie goals
- 17 (68%)
Time in euglycemic range, medication effect score, blood pressure, plasma lipids
- Did not differ among groups
Safety
- No serious adverse events were reported
Original publication
Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes: A Randomized Clinical Trial. JAMA Netw Open. Published 2 October 2023. doi:10.
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