Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity : A Randomized Controlled Trial
Authors' conclusion
In the setting of isocaloric eating, TRE did not decrease weight or improve glucose homeostasis relative to a UEP, suggesting that any effects of TRE on weight in prior studies may be due to reductions in caloric intake.
Study context
- Population
- Adults with obesity and prediabetes or diet-controlled diabetes, clinical research unit; mean age 59 years, 93% women, 93% Black, mean BMI 36 kg/m²randomized 1:1
- Participants
- 41 adults
- Comparison
- Time-restricted eating vs usual eating pattern, isocaloric
- Primary endpoint
- Change in body weight
- Follow-up
- 12 weeks
Methodological detailsisocaloric feeding study, single-site
- Isocaloric feeding study
- Single-site
Primary result
Weight decrease
Average difference
0.3 kg
CI −1.2 to 1.9
By group
Between TRE and UEP
average difference 0.3 kg (CI −1.2 to 1.9)
As reported in the abstract
Secondary outcomes
Baseline weight
Glycemic measures (fasting glucose, homeostatic model assessment for insulin resistance (HOMA-IR), OGTT glucose AUC, glycated albumin) · 12 weeks
- Change in glycemic measures did not differ between groups
Original publication
Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity : A Randomized Controlled Trial. Ann Intern Med. Published 19 April 2024. doi:10.
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