Association between body mass index (BMI)-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study
Authors' conclusion
The present study suggested that MUH-NW individuals had a significant association with increased risk of ICAS compared with MH-NW individuals.
Study context
- Population
- Participants of the Asymptomatic Polyvascular Abnormalities Community (APAC) study, categorized into six groups by BMI and metabolic syndrome (MetS) status; Intracranial atherosclerotic stenosis (ICAS) assessed by transcranial Doppler US
- Participants
- 5,355 participants
- Exposure
- BMI-based metabolic phenotypes vs metabolic healthy normal weight
- Outcome
- ICAS
Methodological detailscommunity-based (APAC study)
- Community-based (APAC study)
Main finding
As reported in the abstract
Each group vs MH-NWFull-adjusted OR (95% CI)
MUH-NWhigher risk of ICAS
1.91(1.42–2.57)
MUO
1.07(0.70–1.65)
- Diagnosed with ICAS (all participants)
- 704
Observational data: associations, not effects.
Further findings
- Results consistent across gender, age, smoking, alcohol intake and physical activity subgroups
Original publication
Association between BMI-based metabolic phenotypes and prevalence of intracranial atherosclerotic stenosis: a cross-sectional study. Int J Obes (Lond). Published 18 April 2024. doi:10.
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