Relationship between maternal obesity and first-trimester thyroid-stimulating hormone (TSH) in women with negative anti-TPO antibodies
Authors' conclusion
Overweight/obesity is significantly related with TSH serum levels in AbTPO-negative pregnant women, independently from the other risk factors for hypothyroidism during pregnancy. The increase of TSH levels could be clinically relevant, as suggested by its association with abnormal UtA-PI, a surrogate marker of abnormal placentation.
Study context
- Population
- AbTPO-negative pregnant women at their first antenatal visit
- Participants
- 2,268 women
- Exposure
- Obese vs overweight vs normal weight
- Normal weightn = 1,693reference
- Overweightn = 435
- Obesen = 140
- Outcome
- First-trimester TSH by BMI
- Follow-up
- First trimester
Main finding
As reported in the abstract
TSH
Obese
1.8
IQR 1.4–2.4 · mU/L
Normal weight
1.6
IQR 1.2–2.2 · mU/L
Overweight
1.6
median · IQR 1.2–2.2 · mU/L
P < 0.001
Observational data: associations, not effects.
Further findings
Risk of TSH ≥4 mU/L per BMI (logistic regression)
- OR for TSH ≥4 mU/L with BMI, independent of non-thyroid autoimmunity, smoking or familiar predisposition for thyroid diseases
- OR: 1.125, 95% CI: 1.080-1.172, P < 0.001
BMI–TSH relationship
- Non-linear relationship between BMI and TSH (restricted cubic splines)
Uterine artery pulsatility index (UtA-PI)
- Women with TSH ≥4 mU/L had a higher UtA-PI, independently from BMI
Original publication
Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies. Eur Thyroid J. Published 18 April 2024. doi:10.
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