Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans
Authors' conclusion
The present study supports the importance of β2-AR in the sympathetic regulation of BAT thermogenesis in humans. The present collection of DNA samples is the largest to which information on the donor's BAT activity has been assigned and can serve as a reference for further in-depth understanding of human BAT function.
Study context
- Population
- Healthy Japanese adults (discovery, mild cold exposure 19 °C, 2 h, FDG-PET/CT); 277 healthy East Asian adults in two independent replication populations (near-infrared time-resolved spectroscopy (NIRTRS) or infrared thermography (IRT)); 42 healthy Japanese adult males under intensive cold exposurediscovery cohort
- Participants
- 399 adults
- Comparison
- Single nucleotide polymorphisms (SNPs) in ADRB1, ADRB2 and ADRB3 and brown adipose tissue (BAT) activity
- Outcome
- BAT activity assessed with FDG-PET/CT under mild cold exposure
Methodological detailsreplication in two independent populations
- Replication in two independent populations
Main finding
As reported in the abstract
Association of ADRB2 SNP rs1042718 with BAT activity (FDG-PET/CT)
- Significant association between functional SNP rs1042718 in ADRB2 and BAT activity
- p < 0.001
Further findings
rs1042718 and cold-induced thermogenesis (population subset)
- rs1042718 also associated with cold-induced thermogenesis in the population subset
Replication: rs1042718 and BAT activity by NIRTRS or IRT
- Association replicated in two other independent populations
- P < 0.05
rs1042718 and responses to intensive cold exposure
- No association with oxygen consumption and cold-induced thermogenesis under intensive cold exposure
ADRB1 and ADRB3 SNPs and BAT-related traits
- SNPs of ADRB1 and ADRB3 not associated with these BAT-related traits
Original publication
Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans. Int J Obes (Lond). Published 17 April 2024. doi:10.
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