UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors
Authors' conclusion
18F-FDG uptake by BAT and UCP1 expression are preserved in young obese adults. Older subjects retain precursor cells with the capacity to form new thermogenic adipocytes. These data highlight the therapeutic potential of BAT mass expansion and activation in obesity.
Study context
- Population
- Human brown adipose tissue (BAT) and white adipose tissue (WAT) samples and differentiated brown and white pre-adipocytes; young normal-weight and obese volunteers for in vivo 18F-FDG PET during mild cold exposure
- Participants
- 53 tissue samples
- Comparison
- UCP1 expression in BAT vs WAT and differentiated pre-adipocytes by age, obesity and cardiometabolic risk factors; young obese vs normal-weight volunteers (18F-FDG PET)
- Outcome
- UCP1 expression as a marker of thermogenic capacity
Methodological detailscase-control study (in vivo arm)
- Case-control study (in vivo arm)
Main finding
As reported in the abstract
UCP1 expression
- UCP1 expression in BAT, but not in WAT or differentiated pre-adipocytes, was reduced with increasing age, obesity and adverse cardiometabolic risk factors (fasting glucose, insulin, blood pressure)
- UCP1 expression in BAT was preserved in obese subjects <40 years of age
Further findings
18F-FDG uptake by BAT and BAT volume during mild cold exposure
- 18F-FDG uptake by BAT and BAT volume were similar between young obese and normal-weight volunteers, despite increased insulin resistance
- Case-control study
Original publication
UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors. Eur J Endocrinol. Published 26 June 2024. doi:10.
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