Risk of fractures following bariatric surgery with Roux-en-Y gastric bypass or sleeve gastrectomy: a Danish population-based cohort study
Authors' conclusion
Bariatric surgery increased the risk of any fracture and MOF to similar extend. Risks were similar for RYGB and SG. However, SG had a shorter follow-up than RYGB, and the cohort size was rather small. More research is needed for long-term SG fracture risk assessment. The use of AOM was low in all cohorts.
Study context
- Population
- Patients treated with RYGB or sleeve gastrectomy (SG) in Denmark, 2006 to 2018, and an age- and sex-matched cohortmatched cohort
- Participants
- 16,121 / 1,509 / 407,580
- Exposure
- RYGB or SG vs age- and sex-matched general population cohort
- RYGBn = 16,121
- SGn = 1,509
- General populationn = 407,580reference
- Outcome
- Any fracture and major osteoporotic fractures (MOF) (also use of anti-osteoporosis medication)
Methodological detailsnationwide, age- and sex-matched comparison cohort, Cox regression adjusted for comorbidities
- Nationwide
- Age- and sex-matched comparison cohort
- Cox regression adjusted for comorbidities
Main finding
As reported in the abstract
Any fracture
Each group vs general populationHazard ratio (95% CI)
RYGB
1.56(1.48–1.64)
SG
1.38(1.13–1.68)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| MOFRYGBvs General populationAdjusted | 1.49 (1.35–1.64) | |
| MOFSGvs General populationAdjusted | 1.43 (0.97–2.12) | |
| 0.512Hazard ratio (log scale) |
Use of anti-osteoporosis medication
- Low but similar in all cohorts
- ≈1%
Original publication
Risk of fractures following bariatric surgery with Roux-en-Y gastric bypass or sleeve gastrectomy: a Danish population-based cohort study. Eur J Endocrinol. Published 25 June 2024. doi:10.
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