Expression of p53 in human adipose tissue correlates positively with FAS and body mass index (BMI)
Authors' conclusion
Taken together, our data suggest that Fas regulates p53 expression in adipocytes, and may thereby affect body weight gain and insulin sensitivity.
Study context
- Population
- Adipocyte-specific Fas-knockout mice, cultured adipocytes, differentiated human mesenchymal stem cells and human white adipose tissue (WAT) from different anatomical depots
Main finding
As reported in the abstract
- p53 protein levels reduced in primary white adipocytes of adipocyte-specific Fas-knockout mice
- Fas ligand (FasL) treatment increased p53 concentrations in cultured adipocytes and decreased mitochondrial oxygen consumption in control but not p53-depleted cells
- FAS expression positively associated with p53 in differentiated human mesenchymal stem cells and WAT from different depots
- p53 expression in human subcutaneous and visceral WAT correlated positively with BMI
- p53 expression in visceral WAT inversely associated with insulin sensitivity (hyperinsulinemic-euglycemic clamp)
Original publication
Expression of p53 in human adipose tissue correlates positively with FAS and BMI. Int J Obes (Lond). Published 1 December 2024. doi:10.
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