Brown Adipose Tissue Activation in Humans Increases Plasma Levels of Lipid Mediators
Authors' conclusion
These results indicate that selected lipid mediators may serve as biomarkers of BAT activation.
Study context
- Population
- Healthy female subjects
- Participants
- 8 vs 14
- Comparison
- Cold exposure and mirabegron treatment as brown adipose tissue (BAT) activation approaches
- Cold exposuren = 8
- Mirabegronn = 14
- Outcome
- Plasma lipid mediators
Main finding
As reported in the abstract
- Cold exposure acutely increased lipoxygenase and cyclooxygenase products (12-HEPE, 12-HETE, 5-HETE, 14-HDHA, MaR2 isomer, 17-HDHA, protectin D1 (PD1), prostaglandin E2)
- Mirabegron similarly increased these products acutely; some mediators blunted after chronic treatment
- MaR2 isomer, 17-HDHA, 5-HETE and 15-HETE positively correlated with nonesterified fatty acids and negatively with respiratory quotient
- PD1, 15-HETE and 5-HETE positively correlated with adiponectin
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Brown Adipose Tissue Activation in Humans Increases Plasma Levels of Lipid Mediators. J Clin Endocrinol Metab. Published 10 January 2024. doi:10.
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