Obesity

Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders

Int J Obes (Lond)Published Registry-based cross-sectional analysis

Authors' conclusion

Health care professionals caring for youth with overweight or obesity should be aware of comorbid mental disorders and regular mental health screening should be considered.

Study context

Population
Children, adolescents and young adults (age 6–30 years) with overweight or obesity, 226 centers in Germany and Austria (APV registry)3,969 with mental disorder
Participants
114,248 children
Exposure
Youth with overweight/obesity and mental disorders vs those without reported mental disorders
Outcome
Clinical characteristics and outcome of youth with overweight or obesity having comorbid mental disorders
Methodological detailsmulticentre, 226 centers in Germany and Austria, Adiposity Patient Registry (APV), regression modeling
  • Multicentre
  • 226 centers in Germany and Austria
  • Adiposity Patient Registry (APV)
  • Regression modeling

Main finding

As reported in the abstract

Mental health comorbidity
Mental health comorbidity reported
3969 out of 114,248
ADHD (among those with comorbidity)
42.5%
Anxiety disorders
31.3%
Depression
24.3%
Eating disorders
12.9%

Observational data: associations, not effects.

Further findings

OutcomeValuesP value
Mean BMI-SDSDepression vs No reported mental disorder · higher with depression · regression analysisDepression mean 2.13 (lower; upper mean 2.09–2.16) · Eating disorders mean 2.22 (lower; upper mean 2.17–2.26) · ADHD mean 1.91 (lower; upper mean 1.89–1.93) · No reported mental disorder mean 2.008 (lower; upper mean 2.005–2.011)P < 0.001
Mean BMI-SDSEating disorders vs No reported mental disorder · higher with eating disorders · regression analysisP < 0.001
Mean BMI-SDSADHD vs No reported mental disorder · lower with ADHD · regression analysisP < 0.001
Severe obesityBetween Mental disorder groups and No reported mental disorderDepression 23.7% · Anxiety disorders 17.8% · Eating disorders 33.3% · ADHD 10.3% · No reported mental disorder 13.5%P < 0.002
  • Severe obesity: higher with depression, anxiety and eating disorders; lower with ADHD

Factors associated with mental health comorbidity

Male sex, OR
1.39 (1.27;1.52) (95% CI)
Older age, OR
1.42 (1.25;1.62)
Extreme obesity, OR
1.45 (1.30;1.63)

Dyslipidaemia and abnormal carbohydrate metabolism

Not different in youth with and without reported mental health comorbidity

BMI-SDS change after lifestyle intervention program · one year

BMI-SDS change range; similar in youth without and with different mental disorders
−0.22 and −0.16

Original publication

Clinical characteristics and outcomes of children, adolescents and young adults with overweight or obesity and mental health disorders. Int J Obes (Lond). Published 9 January 2024. doi:10.1038/s41366-023-01449-4

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