Quantitative Magnetic Resonance Imaging (MRI) Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity
Authors' conclusion
Our findings are consistent with the presence of neuroinflammation in brain regions involved in food intake. In vivo brain biomarkers from quantitative MRI appear to provide an incremental information for the assessment of brain damages in patients with obesity.
Study context
- Population
- Patients with obesity and normal-weight controls, Specialized Center for the Care of Obesity, French University Hospital, May 2019–November 2022
- Participants
- 27 vs 23
- Comparison
- Patients with obesity vs normal-weight controls
- Obesityn = 27
- Normal-weight controlsn = 23reference
- Outcome
- Brain MRI parametric maps: QSM, mean diffusivity (MD), fractional anisotropy (FA), magnetization transfer ratio map, T2 relaxivity map
Methodological detailssingle-centre, age and gender-paired controls
- Single-centre
- Age and gender-paired controls
Main finding
As reported in the abstract
Quantitative brain MRI metrics
- Hypothalamus: higher fractional anisotropy (FA) and lower quantitative susceptibility mapping (QSM) with obesity vs normal-weight controls
- Hippocampus: higher FA and lower MD with obesity
Observational data: associations, not effects.
Further findings
- No correlation between imaging biomarkers and eating behavior or anxiety
Original publication
Quantitative MRI Biomarkers Measure Changes in Targeted Brain Areas in Patients With Obesity. J Clin Endocrinol Metab. Published 9 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →