The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: National Health and Nutrition Examination Survey (NHANES) 2003–2018
Authors' conclusion
TyG-WC and TyG-WtHR enhance CVD mortality prediction, diagnostic efficacy of CVD and its mortality, and correlation with some CVD over and above the current hottest TyG. TyG-WC and TyG-WtHR are expected to become more effective metrics for identifying populations at early risk of cardiovascular disease and improve risk stratification.
Study context
- Population
- US adults, NHANES 2003–2018
- Participants
- 11,937 adults
- Exposure
- Triglyceride-glucose (TyG) index and TyG combined with obesity indicators (TyG-WC, TyG-WHtR, TyG-BMI) in relation to cardiovascular disease (CVD) and CVD mortality
- Outcome
- CVD and CVD mortality
Main finding
As reported in the abstract
Estimate (95% CI)
TyG-WHtRCVD mortality; strongest predictor
HR 1.66(1.21–2.29)
TyGcoronary heart disease
OR 2.52(1.66–3.83)
TyG-WCtotal CVD
OR 2.37(1.77–3.17)
TyG-WCcongestive HF
OR 2.14(1.31–3.51)
TyG-WCangina pectoris
OR 2.38(1.43–3.97)
TyG-WHtRMI
OR 2.24(1.45–3.44)
Observational data: associations, not effects.
Further findings
Linearity (restricted cubic spline (RCS))
- Most relationships linear
- P-overall < 0.0001, P-nonlinear > 0.05
Diagnostic efficacy (ROC)
- TyG-WHtR and TyG-WC had more robust diagnostic efficacy than TyG
Mediation
- HbA1c mediated all relationships; insulin mediated some
Original publication
The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018. Cardiovasc Diabetol. Published 6 January 2024. doi:10.
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