Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts
Authors' conclusion
An elevated TyG index and its related indices are significantly correlated with an increased risk of CVD and related mortality across three national cohorts. These indices are anticipated to serve as valid predictors of incident CVD and mortality in individuals with hypertension.
Study context
- Population
- Hypertensive individuals from National Health and Nutrition Examination Survey (NHANES), UK Biobank and Shanghai Pudong cohort9,283, 164,357 and 5,334 in three cohorts
- Exposure
- Higher vs lower TyG index and TyG-obesity indices
- Outcome
- CVD incidence and mortality by TyG-related indices
Methodological detailsthree cohorts (NHANES, UK Biobank, Shanghai Pudong), multivariate Cox proportional hazards models, Generalized Additive Models, mediation analysis
- Three cohorts (NHANES, UK Biobank, Shanghai Pudong)
- Multivariate Cox proportional hazards models
- Generalized Additive Models
- Mediation analysis
Main finding
As reported in the abstract
- Higher TyG-WHTR and all-cause mortality, UKBB: HR
- 1.21 (95% CI 1.16-1.26)
- Higher TyG-WHTR and all-cause mortality, NHANES: HR
- 1.17 (95% CI 1.00-1.36)
- Higher TyG-WHTR and cardiovascular disease (CVD) mortality, UKBB: HR
- 1.36 (95% CI 1.23-1.49)
- Higher TyG-WHTR and CVD mortality, NHANES: HR
- 1.32 (95% CI 1.00-1.72)
- Pudong cohort, higher TG/HDL-C ratio and CVD: HR
- 1.31 (95% CI 1.00-1.73)
- Pudong cohort, higher TG/HDL-C ratio and stroke: HR
- 1.67 (CI 1.06-2.63)
Observational data: associations, not effects.
Further findings
Mediation by inflammatory markers
- Systemic inflammatory response index (SIRI) and C-reactive protein (CRP) partially explained these links, CRP with a stronger effect
Genetically predicted TyG and stroke (Mendelian randomization)
- OR
- 1.26 (95% CI 1.10-1.45)
Original publication
Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts. Cardiovasc Diabetol. Published 8 January 2025. doi:10.
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