Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial
Primary result · Change in prespecified dominant LC symptomResult — go to the resultTreatment effect −0.34 95% CI −0.67 to −0.01Study context
- Population
- Adults with long COVID (symptoms >12 weeks) and BMI >27 kg m-2 (>25 kg m-2 for South Asians)randomized 1:1
- Participants
- 234 adults
- Comparison
- Remotely delivered structured weight management vs control
- Weight managementn = 118
- Controln = 116reference
- Primary endpoint
- Change in the participant-selected dominant long COVID symptom (fatigue, breathlessness, pain, anxiety/depression or other), assessed with validated questionnaires or a visual analog scale
- Follow-up
- 6 months
Methodological detailswait-list-controlled, open-label, randomized 1:1 via minimization and randomization (80:20)
- Wait-list-controlled
- Open-label
- Randomized 1:1 via minimization and randomization (80:20)
Primary result
Change in prespecified dominant Long COVID (LC) symptom
Treatment effect
−0.34
95% CI −0.67 to −0.01
Change by group
Intervention
−1.16
SD 1.42
Control
−0.83
SD 1.14
As reported in the abstract
Safety
- No excess of serious adverse events
Original publication
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial. Nat Med. Published 8 January 2025. doi:10.
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