A Diabetes Remission Clinical Trial (DiRECT) approach to weight loss in a culturally diverse, low‐income population: Pilot randomised controlled trial and meta‐analysis of similar interventions
Pooled result · Weight lossResult — go to the resultDifference −6.1 kg 95% CI −10.2 to −2.0Authors' conclusion
In this pilot effectiveness trial, the DiRECT-type intervention generated clinically relevant and greater weight loss than dietitian-supported usual care at 3 and 12 months. These results align with the effect sizes generated by meta-analyses of existing DiRECT-type interventions, demonstrating the potential use of DiRECT-type approaches across a much broader spectrum of the population than previously considered including those with both type 2 and prediabetes.
Study context
- Population
- Adults with obesity, T2D or prediabetes, and a desire to lose weight, in a primary care service catering to indigenous (Māori), Pacific, refugee and low-income clientele
- Participants
- 40 adults
- Comparison
- DiRECT-type intervention vs dietitian-supported usual care
- Outcome
- Weight loss
- Follow-up
- 3 and 12 months
Methodological detailseffectiveness trial, random-effects meta-analysis, primary care
- Effectiveness trial
- Random-effects meta-analysis
- Primary care
Pooled result
As reported in the abstract
3 months
Difference
−6.1 kg
95% CI −10.2 to −2.0
DiRECT-type interventionvs Dietitian-supported usual care
difference −6.1 kg (95% CI −10.2 to −2.0)
Further pooled results
| Outcome | Difference (kg) (CI) | |
|---|---|---|
| Weight loss · 12 monthsCo-primary time point | −3.8 (−7.6 to −0.1) | |
| Meta-analysis: weight loss, DiRECT-type interventions vs usual diabetes care (with or without dietary advice) · 3 and 12 monthsDiRECT-type interventionvs Usual diabetes care3 months; greater weight loss with DiRECT-type · random-effects meta-analysis | −8.5 (−11.1 to −5.9) | |
| Meta-analysis: weight loss, DiRECT-type interventions vs usual diabetes care (with or without dietary advice) · 3 and 12 monthsDiRECT-type interventionvs Usual diabetes care12 months; greater weight loss with DiRECT-type · random-effects meta-analysis | −6.0 (−8.4 to −3.5) | |
| −15−10−505Difference, kg (linear scale) |
- Weight loss: due to gradual weight loss with usual care, not weight regain in DiRECT
Original publication
A DiRECT approach to weight loss in a culturally diverse, low‐income population: Pilot randomised controlled trial and meta‐analysis of similar interventions. Diabetes Obes Metab. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →