Weight loss following lisdexamfetamine in children and adolescents with attention deficit hyperactivity disorder and overweight and obesity
Authors' conclusion
Reduction in BMI for age was noted for up to 2 years following initiation of lisdexamfetamine in children with ADHD and overweight and obesity. Further studies are warranted to study the weight loss effect of lisdexamfetamine in children with obesity.
Study context
- Population
- Children aged 2 to <18 years treated with lisdexamfetamine for attention deficit hyperactivity disorder (ADHD); median age 10 years (IQR 8.1–13), 68% male
- Participants
- 330 children
- Exposure
- Severe obesity vs Mild-moderate obesity vs Overweight vs Healthy weight
- Severe obesityn = 55
- Mild-moderate obesityn = 88
- Overweightn = 131
- Healthy weightn = 56
- Outcome
- Change in weight status (BMI) after initiation of lisdexamfetamine
- Follow-up
- Up to 2 years
Methodological detailslinear mixed effects models with autoregressive-1 correlation structure
- Linear mixed effects models with autoregressive-1 correlation structure
Main finding
As reported in the abstract
Change in BMI Z-score
| Group | Value | p |
|---|---|---|
| Severe obesity | −0.41 (95% CI −0.57–-0.25) | p < 0.001 |
| Mild-moderate obesity | −0.44 (95% CI −0.56–-0.31) | p < 0.001 |
Value
Severe obesity−0.41 (95% CI −0.57–-0.25)
Mild-moderate obesity−0.44 (95% CI −0.56–-0.31)
p
Severe obesityp < 0.001
Mild-moderate obesityp < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Severe obesity | Mild-moderate obesity |
|---|---|---|
| Change in BMI percent of the 95th percentile · 2 years (24 months) | −11.2% (95% CI −15.8–-6.7) | −11.1% (95% CI −13.9–-8.4) |
| p | p < 0.001 | p < 0.001 |
Body mass index (BMI) reduction by age (ages 4-10 vs older)
- Younger children (ages 4-10) showed greater BMI reduction, mild-moderate obesity
- P < 0.001
- Younger children (ages 4-10) showed greater BMI reduction, overweight
- P = 0.029
Original publication
Weight loss following lisdexamfetamine in children and adolescents with attention deficit hyperactivity disorder and overweight and obesity. Pediatr Obes. Published 15 May 2025. doi:10.
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