Association of novel metabolic status with asymptomatic intracranial arterial stenosis: A cross-sectional study
Main finding · aICASResult — go to the resultOdds ratio 2.02 95% CI 1.11–3.68Authors' conclusion
MU defined by the new criterion was significantly associated with aICAS, especially with moderate-to-severe aICAS. This novel criterion effectively identifies individuals with a high prevalence of aICAS among populations with obesity, which could be crucial for stroke prevention.
Study context
- Population
- Adults aged ≥40 years without history of clinical stroke or TIA, rural China, RICAS cohortRICAS cohort
- Participants
- 2,005 adults
- Exposure
- Metabolically unhealthy (MU) vs metabolically healthy (MH) status, defined by a new criterion
- MUn = 1,597
- Outcome
- aICAS
Main finding
As reported in the abstract
Odds ratio
2.02
95% CI 1.11–3.68
P = 0.021
MUvs MH
OR 2.02 (95% CI 1.11–3.68); P = 0.021
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Moderate-to-severe aICAS | 2.43 (1.04–5.72) | P = 0.042 | |
| 0.20.5125Odds ratio (log scale) |
Asymptomatic intracranial arterial stenosis (aICAS) by metabolic status and obesity
| OR (95% CI) | P value | ||
|---|---|---|---|
| MUNMetabolically unhealthy normal-weight | 2.11 (1.10–4.03) | P = 0.025 | |
| MUOMetabolically unhealthy obesity | 3.30 (1.64–6.64) | P = 0.001 | |
| 0.10.31310Odds ratio (log scale) |
aICAS prevalence by number of metabolic disorders
- Prevalence of aICAS increased with the number of metabolic disorders
- P for linear trend < 0.001
aICAS by metabolic status and obesity
- Metabolically healthy obesity (MHO) not significantly correlated with aICAS
aICAS by sex (subgroup)
- MU–aICAS association confirmed only in men
- P for interaction = 0.042
Original publication
Association of novel metabolic status with asymptomatic intracranial arterial stenosis: A cross-sectional study. Int J Obes (Lond). Published 25 January 2025. doi:10.
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