Metabolically healthy abdominal obesity is associated with higher odds of left ventricular geometric remodeling in children: Evidence from two school-based studies in China
Authors' conclusion
MHO is associated with a higher likelihood of LVG remodeling, suggesting that this phenotype may not be benign for the heart in children. Due to its simplicity and practicality, WHtR may be a preferable tool for the rapid screening of children with abdominal obesity and associated cardiac risk.
Study context
- Population
- Chinese children aged 6–11 years, two school-based studies in China
- Participants
- 2,866 children
- Exposure
- MHO vs metabolically healthy normal waist-to-height ratio (WHtR)
- MHOn = 543
- Outcome
- LVG remodeling (normal geometry, concentric remodeling, eccentric hypertrophy, concentric hypertrophy) by left ventricular mass index and relative wall thickness
Methodological detailstwo school-based studies, multivariable logistic regression
- Two school-based studies
- Multivariable logistic regression
Main finding
As reported in the abstract
LVG remodeling (WHtR-defined abdominal obesity)
MHO vs Metabolically healthy normal WHtRAdjusted odds ratio (95% CI)
Left ventricular hypertrophy
4.78(3.44–6.64)
High relative wall thickness
1.81(1.33–2.47)
Concentric remodeling
1.45(1.01–2.08)
Eccentric hypertrophy
4.37(3.01–6.33)
Concentric hypertrophy
7.50(3.77–14.91)
- Children classified as MHO (WHtR)
- 543 (18.9%)
Observational data: associations, not effects.
Further findings
Left ventricular geometric (LVG) remodeling with abdominal obesity defined by waist circumference
- Similar results to WHtR definition
Original publication
Metabolically healthy abdominal obesity is associated with higher odds of left ventricular geometric remodeling in children: Evidence from two school-based studies in China. Int J Obes (Lond). Published 22 May 2025. doi:10.
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