Association of metabolically healthy obesity with risk of heart failure and left ventricular dysfunction among older adults
Authors' conclusion
Among older individuals, the metabolic health status might modify the association of obesity with risk of HF and LV diastolic dysfunction. Worse LV diastolic function and higher risk of HF were just noted in individuals with MUO, but not in those with MHO.
Study context
- Population
- Older adults grouped into four metabolic phenotypes by obesity and metabolic statusprimary cohort
- Participants
- 6,335 adults
- Exposure
- Metabolic phenotypes vs MHN
- Outcome
- Risk of HF
Methodological detailsseparate longitudinal validation cohort
- Separate longitudinal validation cohort
Main finding
As reported in the abstract
HF risk
Each group vs MHNOdds ratio (95% CI)
MUN
1.51(1.14–1.99)
MUO
2.01(1.39–2.91)
MHO
0.86(0.30–2.43)
- Participants diagnosed with heart failure (HF) in primary cohort
- 434
Observational data: associations, not effects.
Further findings
Left ventricular (LV) diastolic function
- Worse LV diastolic function in MUN and metabolically unhealthy obesity (MUO), not metabolically healthy obesity (MHO)
HF risk in validation cohort
- MHO not associated with HF risk in the validation cohort
Original publication
Association of metabolically healthy obesity with risk of heart failure and left ventricular dysfunction among older adults. Int J Obes (Lond). Published 9 October 2024. doi:10.
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