Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state
Authors' conclusion
Physical activity, education and depressive symptoms differed between MHO and MUO, even when mutually adjusted for, but did not predict conversion from a metabolically healthy to unhealthy state. Although not statistically significant, the results indicated that those with genetically predicted high BMI are more likely to maintain MHO and not convert to a metabolically unhealthy state.
Study context
- Population
- Individuals with obesity, Health and Retirement Study, 2006–2016
- Participants
- 9,809 individuals
- Exposure
- Metabolically healthy obesity (MHO) vs metabolically unhealthy obesity (MUO)
- Outcome
- Differences in physical activity, education, depressive symptoms and polygenic score for higher body mass index (BMI) (PGSBMI) between MHO and MUO; prediction of conversion from MHO to a metabolically unhealthy state
- Follow-up
- 4 years (conversion)
Methodological detailscross-sectional and longitudinal analysis
- Cross-sectional and longitudinal analysis
Main finding
As reported in the abstract
Factors associated with MHO vs MUO (cross-sectional)
Physical activity (MHO higher), OR
0.81
Education (MHO higher), OR
0.83
Depressive symptoms (MHO lower), OR
1.14
Observational data: associations, not effects.
Further findings
Conversion from MHO to a metabolically unhealthy state · 4 years
- Higher PGSBMI: lower risk of conversion (p = 0.07)
- 24%
- None of the factors were associated with conversion
Original publication
Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state. Diabetes Obes Metab. Published 9 October 2024. doi:10.
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