Associations of Metabolic Phenotypes with Cardiac Structure and Clinical Outcomes: Insights from the UK Biobank
Authors' conclusion
Metabolic phenotypes show distinct cardiac structural changes and increased mortality risk, supporting their potential in cardiovascular risk stratification.
Study context
- Population
- UK Biobank participants with CMR; mean age 64.1 ± 7.5 years, 52.6% female
- Participants
- 22,789 participants
- Exposure
- Metabolic phenotypes vs metabolically healthy nonobese
- Outcome
- MACE
- Follow-up
- median 5.1-year follow-up
Methodological detailspopulation-based, adjusted for age, sex and smoking
- Population-based
- Adjusted for age, sex and smoking
Main finding
As reported in the abstract
Each group vs MHNAdjusted hazard ratio (CI)
MUN
1.55(1.16–2.07)
MUO
1.95(1.28–2.97)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (CI) | |
|---|---|---|
| All-cause mortalityMHOvs MHN | 1.65 (1.23–2.21) | |
| All-cause mortalityMUNvs MHN | 1.41 (1.05–1.90) | |
| All-cause mortalityMUOvs MHN | 2.10 (1.41–3.15) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | β (CI) |
|---|---|
| LV wall thickness (CMR)MHO vs MHN | .53 (.50, .55) |
| LV wall thickness (CMR)MUN vs MHN | .24 (.21, .27) |
| LV wall thickness (CMR)MUO vs MHN | .66 (.61, .70) |
| LVEDV (CMR)MHO vs MHN | 4.67 (4.07–5.27) |
| LVEDV (CMR)MUO vs MHN | 5.14 (4.05–6.22) |
| LVEDV (CMR)MUN vs MHN | −1.25 (−1.95, −.55) |
| LVEF (CMR)MUO vs MHN | −.48 (−.91, −.04) |
Original publication
Associations of Metabolic Phenotypes with Cardiac Structure and Clinical Outcomes: Insights from the UK Biobank. J Clin Endocrinol Metab. Published 22 December 2025. doi:10.
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