Obesity

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery

Clin Endocrinol (Oxf)Published Prospective cohort study

Authors' conclusion

These findings suggest that although overall ApoJ levels did not change significantly, individual temporal variations were associated with changes in leptin levels, indicating that ApoJ may serve as a potential biomarker after RYGB.

Study context

Population
Obese patients undergoing RYGB surgery
Participants
7 patients
Outcome
Serial changes in ApoJ levels and their associations with responses of adiponectin levels and metabolic parameters
Follow-up
From 1 day up to 12 months post-surgery

Main finding

As reported in the abstract

ApoJ levels after RYGB · up to 12 months

Positive association of Apolipoprotein J (ApoJ) changes with changes in leptin levels

r² = 0.499

p = 0.024

Observational data: associations, not effects.

Further findings

Anthropometric and metabolic parameters · post-surgery

Marked improvements in anthropometric measures and serum glucose, insulin, leptin, GLP-1, adiponectin, homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA-ß

Original publication

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery. Clin Endocrinol (Oxf). Published 21 December 2025. doi:10.1111/cen.70087

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