Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture
Authors' conclusion
RYGB was associated with detrimental effects on osteometabolism biomarkers, as well as on density and structural parameters of BM. Early preventive strategies aimed at mitigating these deleterious effects should be systematically evaluated to minimize their long-term impact.
Study context
- Population
- Patients 2–5 years after RYGB (aged 39 ± 5 years, BMI 42.2 ± 3.8 kg/m²) and non-surgical matched controls
- Participants
- 39 vs 21
- Exposure
- RYGB 2-5 years after surgery vs non-surgical controls
- BGn = 39
- CGn = 21reference
- Outcome
- Osteometabolism biomarkers, BMD and bone microarchitecture
Methodological detailsage-, sex- and BMI-matched controls
- Age-, sex- and BMI-matched controls
Main finding
As reported in the abstract
- BG had higher circulating phosphorus, parathyroid hormone (PTH), CTX-1 and P1NP and lower 25(OH) vitamin D vs CG
- DXA parameters did not differ between groups
- HR-pQCT showed significant derangements in bone microarchitecture (BM) (trabecular thickness, cortical bone density, outer trabecular volumetric BMD) in BG
- BG showed tibia-specific trabecular microarchitecture impairment; sex and BMI showed the expected associations with BM measures
Observational data: associations, not effects.
Original publication
Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture. Obesity (Silver Spring). Published 17 February 2026. doi:10.
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