Bone mineral density in young adults 5 to 11 years after adolescent metabolic and bariatric surgery for severe obesity compared to peers
Authors' conclusion
BMD, especially of the hip and femoral neck, was lower in young adults who underwent MBS during adolescence compared to matched peers who had not undergone MBS. BMD Z-scores of the femoral neck were inversely associated with time since MBS but were not associated with BMI change.
Study context
- Population
- Young adults 5 to 11 years after adolescent metabolic and bariatric surgery (MBS) for severe obesity (Teen-LABS cohort), bone mineral density (BMD) measured 2016–2022; controls without MBS106 cases · 91 controls
- Participants
- 58 / 48 / 91
- Exposure
- Adolescent RYGB or vertical sleeve gastrectomy (VSG) vs controls without MBS
- RYGBn = 58
- VSGn = 48
- Controlsn = 91reference
- Outcome
- BMD by DXA
- Follow-up
- 5 to 11 years after MBS
Methodological detailscontrolled comparison with peers, Teen-LABS cohort
- Controlled comparison with peers
- Teen-LABS cohort
Main finding
As reported in the abstract
Adjusted mean DXA-BMD vs controls
- RYGB
- difference, hip −10.0 %; P < 0.001
- VSG
- difference, hip −6.3 %; P < 0.001
- RYGB
- difference, femoral neck −9.6 %; P < 0.001
- VSG
- difference, femoral neck −5.7 %; P < 0.001
- RYGB
- difference, ultra-distal radius −7.9 %; P < 0.001
- VSG
- difference, ultra-distal radius −7.0 %; P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Trabecular volumetric BMD (radius and tibia) vs controlsRYGB vs Controls · subset with peripheral quantitative CT | difference, radius −30 % | P < 0.001 |
| Trabecular volumetric BMD (radius and tibia) vs controlsRYGB vs Controls · subset with peripheral quantitative CT | difference, tibia −26 % | P < 0.001 |
| Trabecular volumetric BMD (radius and tibia) vs controlsVSG vs Controls · subset with peripheral quantitative CT | difference, radius −15 % | P < 0.001 |
| Trabecular volumetric BMD (radius and tibia) vs controlsVSG vs Controls · subset with peripheral quantitative CT | difference, tibia −14 % | P < 0.001 |
Time since MBS and BMD Z-scores
- Greater time since MBS associated with lower hip BMD Z-score
- P = 0.05
- Greater time since MBS associated with lower femoral neck BMD Z-score
- P = 0.045
Body mass index (BMI) change and bone measures · median 9.3 years post MBS
- % change in BMI from baseline or in first year after MBS not associated with bone measures
Original publication
Bone mineral density in young adults 5 to 11 years after adolescent metabolic and bariatric surgery for severe obesity compared to peers. Int J Obes (Lond). Published 4 January 2024. doi:10.
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