Association between plasma proteomic dynamic changes and metabolic outcomes in patients undergoing bariatric surgery
Authors' conclusion
This study identified novel inflammatory and metabolic proteins possibly implicated in the systemic metabolic response to BS.
Study context
- Population
- Overweight patients and patients with class I to III obesity undergoing bariatric surgery (BS)sampled before surgery
- Participants
- 114 patients
- Exposure
- Plasma proteins before vs after BS
- Outcome
- Dynamic changes in inflammatory and metabolic-related circulating proteins
- Follow-up
- 1, 3, 6, 12 and 24 months post-surgery
Methodological detailsquantitative plasma proteomic analysis (399 inflammatory/metabolic proteins, Olink Proteomics), repeated sampling before and up to 24 months after surgery, Samples: before (n = 114), 1 month (n = 67), 3 months (n = 64), 6 months (n = 60), 12 months (n = 48), 24 months (n = 18)
- Quantitative plasma proteomic analysis (399 inflammatory/metabolic proteins, Olink Proteomics)
- Repeated sampling before and up to 24 months after surgery
- Samples: before (n = 114), 1 month (n = 67), 3 months (n = 64), 6 months (n = 60), 12 months (n = 48), 24 months (n = 18)
Main finding
As reported in the abstract
Circulating protein changes after BS
- Liver-expressed IGFBP-1/2 upregulated at all time points post-surgery
- Peroxisomal enzyme HAOX1 downregulated at all time points post-surgery
- Strong association between changes in HAOX1 and improvements in liver enzymes
- SSC4D showed the highest decrease among all proteins at 24 months
Observational data: associations, not effects.
Further findings
Inflammatory markers by surgery type and BMI class · 1 month post-surgery
- Inflammatory markers transiently increased after RYGB vs vertical sleeve gastrectomy (VSG), and in severe obesity vs overweight and obesity
Original publication
Association between plasma proteomic dynamic changes and metabolic outcomes in patients undergoing bariatric surgery. Int J Obes (Lond). Published 5 June 2025. doi:10.
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