Association between adiposity distribution and high-sensitivity C-reactive protein, adipokines, interleukins and plasminogen activator inhibitor-1
Authors' conclusion
We found significant differences between limbs' and trunk fat for hsCRP (men), adiponectin (both sexes), leptin (women), and PAI-1 (women), with trunk fat being associated with higher levels of pro-inflammatory markers.
Study context
- Population
- Adults aged 27 years, EPITeen cohort
- Participants
- 546 adults
- Exposure
- Trunk fat vs limbs' fat and markers of inflammation
- Outcome
- Associations of total body fat, limbs' fat and trunk fat with hsCRP, adiponectin, leptin, resistin, IL-1β, IL-6, IL-8, IL-10 and PAI-1
Methodological detailspart of the EPITeen cohort
- Part of the EPITeen cohort
Main finding
As reported in the abstract
- High-sensitivity C-reactive protein (hsCRP), men: trunk β
- 0.065 (0.025, 0.106)
- hsCRP, men: limbs β
- −0.050 (−0.103, 0.004)
- Adiponectin, women: trunk β
- −0.088 (−0.144, −0.032)
- Adiponectin, women: limbs β
- 0.125 (0.054, 0.196)
- Adiponectin, men: trunk β
- −0.084 (−0.124, −0.044)
- Adiponectin, men: limbs β
- 0.073 (0.020, 0.126)
- Leptin, women: trunk β
- 0.037 (0.003, 0.070)
- Leptin, women: limbs β
- 0.116 (0.074, 0.159)
- PAI-1, women: trunk β
- 0.025 (0.006, 0.044)
- PAI-1, women: limbs β
- −0.021 (−0.045, 0.003)
Observational data: associations, not effects.
Original publication
Association between adiposity distribution and high-sensitivity C-reactive protein, adipokines, interleukins and plasminogen activator inhibitor-1. Int J Obes (Lond). Published 3 June 2025. doi:10.
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