Cardiovascular disease risk factors and their associations with inflammation among US adolescents: NHANES, 2015 to March 2020
Authors' conclusion
Among US adolescents, obesity was strongly associated with elevated hs-CRP, a marker for future CVD risk. Given the obesity epidemic and the marked proportion with elevated CRP, concern should be given to future CVD risk in younger adults.
Study context
- Population
- US adolescents aged 12–19 years, NHANES 2015 to March 2020
- Participants
- 2,693 adolescents
- Exposure
- Cardiovascular disease (CVD) risk factors vs their absence, for elevated high-sensitivity C reactive protein (hs-CRP)
- Outcome
- Elevated hs-CRP (>3.0 mg/L)
Methodological detailsnationally representative sample, logistic regression
- Nationally representative sample
- Logistic regression
Main finding
As reported in the abstract
- Adolescents with elevated hs-CRP
- 15.3%
- Obesity vs no obesity, aOR (fully adjusted)
- 6.39 (4.64 to 8.79)
- A1c ≥5.7% vs <5.7%, aOR (fully adjusted)
- 1.70 (1.05 to 3.06)
- Hypertension vs none, aOR (adjusted for sociodemographics; not significant after further adjustment for obesity)
- 2.46 (1.08 to 5.60)
- Hyperlipidemia vs none, aOR (adjusted for sociodemographics; not significant after further adjustment for obesity)
- 2.19 (1.36 to 3.54)
Observational data: associations, not effects.
Further findings
- Older (16-19 vs 12-15 years), obese, A1c ≥5.7% (≥39 mmol/mol), high total cholesterol or low HDL-C: more high-risk hs-CRP distributions
- χ2 p value <0.001
Original publication
Cardiovascular disease risk factors and their associations with inflammation among US adolescents: NHANES, 2015 to March 2020. BMJ Open Diabetes Res Care. Published 3 August 2024. doi:10.
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