Clinical burden of hyperphagia, obesity and health outcomes in paediatric individuals with Bardet‐Biedl syndrome: A CRIBBS data analysis
Authors' conclusion
Hyperphagia and obesity are highly prevalent in children with BBS. Many children with BBS also experience adverse health outcomes. Timely diagnosis and targeted treatment of hyperphagia and obesity are needed.
Study context
- Population
- Paediatric participants (<18 years) with Bardet-Biedl syndrome (BBS) enrolled in the international CRIBBS registry
- Participants
- 331 participants
- Outcome
- Obesity and weight loss interventions
- Follow-up
- Baseline
Methodological detailsinternational registry
- International registry
Main finding
As reported in the abstract
baseline
Obesity at baseline
81.0%
Use of weight loss diet or medication at baseline or later
22.7%
Observational data: associations, not effects.
Further findings
Higher weight classification from first to last assessment (≥2 weight measurements ≥2 years apart)
- Higher weight classification
- 17.2%
- n = 186
Hyperphagia severity and obesity
- Increasing hyperphagia severity was associated with increasing obesity
Cardiac, diabetic, endocrine and renal health outcomes
- Prevalence of cardiac, diabetic, endocrine and renal health outcomes increased with obesity class
Original publication
Clinical burden of hyperphagia, obesity and health outcomes in paediatric individuals with Bardet‐Biedl syndrome: A CRIBBS data analysis. Pediatr Obes. Published 2 June 2025. doi:10.
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