Time-Restricted Eating and Sleep, Mood, and Quality of Life in Adults With Overweight or Obesity: A Secondary Analysis of a Randomized Clinical Trial
Authors' conclusion
In this secondary analysis of a randomized clinical trial of 3 different TRE schedules, incorporating TRE into a UC intervention, regardless of the eating window timing, was not associated with significant changes in sleep, mood, or quality of life compared with UC alone in adults with overweight or obesity. The findings suggest TRE may be a viable nutritional weight management strategy without adverse effects on sleep, mood, or quality of life.
Study context
- Population
- Men and women aged 30 to 60 years with overweight or obesity, Granada and Pamplona (Spain); 49.7% women, mean age 46.1 years, mean BMI 32.8randomized
- Participants
- 197 men
- Comparison
- Early, late or self-selected 8-h time-restricted eating (TRE) plus usual care (UC) vs UC alone
- UCn = 49reference
- Early TREn = 49
- Late TREn = 52
- Self-selected TREn = 47
- Primary endpoint
- Changes in sleep (accelerometry), mood (depression, anxiety, stress) and quality of life (questionnaires)
- Follow-up
- 12-week intervention
Methodological detailsprespecified secondary analysis, multicentre, allocation 1:1:1:1, Conducted April 11, 2022, to March 6, 2023
- Prespecified secondary analysis
- Multicentre
- Allocation 1:1:1:1
- Conducted April 11, 2022, to March 6, 2023
Primary result
As reported in the abstract
Sleep, mood and quality of life: early TRE vs UC · 12 weeks
Early TRE vs UCMean difference, hours (95% CI)
Total sleep time
0.2(−0.2 to 0.6)
Early TRE vs UCMean difference, points (95% CI)
Beck Depression Inventory Fast Screen score
0.2(−1.0 to 1.3)
STAI state anxiety score
−1.2(−6.4 to 4.1)
Perceived Stress Scale score
2.1(−1.8 to 5.9)
SF-36 general health score
3.3(−4.4 to 10.9)
Original publication
Time-Restricted Eating and Sleep, Mood, and Quality of Life in Adults With Overweight or Obesity: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. Published 2 June 2025. doi:10.
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