The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels
Authors' conclusion
RYGB causes a transient reduction in pNT as a consequence of caloric restriction. The RYGB/VSG-induced rise in postprandial pNT is independent of GIP and GLP-1, and higher fasting pNTs are maintained 1 year post surgically.
Study context
- Population
- Cohort 1: 9 normoglycemic (NG) and 10 T2D patients; cohort 2: 10 normal-weight controls and 10 patients with obesity and T2D undergoing RYGB or vertical sleeve gastrectomy (VSG); cohort 3: NG and T2D patients undergoing RYGB
- Comparison
- RYGB vs very low-energy diet (VLED); pre vs post bariatric surgery
- Outcome
- pNT levels
Methodological detailsthree cohorts, mixed-meal tests, GIP and GLP-1 infusions, Cohort 3 fasting proneurotensin (pNT): pre RYGB n = 161, 2 months post n = 92, 1 year post n = 118
- Three cohorts
- Mixed-meal tests
- GIP and GLP-1 infusions
- Cohort 3 fasting pNT: pre RYGB n = 161, 2 months post n = 92, 1 year post n = 118
Main finding
As reported in the abstract
- Reduced fasting and postprandial pNT after VLED and immediately following RYGB
- Reintroduction of solid food post RYGB increased fasting and postprandial pNT
- Before RYGB, all patients lacked a meal response in pNT; evident post RYGB/VSG
- GIP or GLP-1 infusion had no effect on pNT levels
- Fasting pNT higher 1 year post RYGB regardless of glycemic status
Original publication
The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels. J Clin Endocrinol Metab. Published 13 March 2024. doi:10.
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