Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy
Authors' conclusion
These findings suggest that LSG-induced gut microbiome alteration may influence skeletal outcomes postoperatively, and microbial influences on butyrate formation and IGF-1 are possible mechanisms.
Study context
- Population
- Adults with severe obesity undergoing laparoscopic sleeve gastrectomy (LSG)
- Participants
- 23 adults
- Exposure
- Preoperative vs 6 mo after LSG
- Outcome
- Gut microbiome and bone health after LSG
- Follow-up
- 6 mo after LSG
Methodological details16S rRNA gene sequencing; fecal short-chain fatty acids (SCFA) by LC-MS/MS; Spearman's correlations and PERMANOVA
- 16S rRNA gene sequencing; fecal SCFA by LC-MS/MS; Spearman's correlations and PERMANOVA
Main finding
As reported in the abstract
6 mo after LSG
- CTx increase, median
- 188%
- P1NP increase, median
- 61%
- CTx and P1NP increase, P
- P < .01
- Femoral neck BMD change, mean (P < .01)
- −3.3%
- Greater within-subject change in β-diversity vs P1NP increase, ρ (P = .02)
- 0.48
- Greater within-subject change in β-diversity vs femoral neck bone loss, ρ (P = .04)
- −0.43
- Within-participant shift in α-diversity vs change in IGF-1, ρ (P < .01)
- 0.56
- Postoperative fecal butyrate vs IGF-1 level, ρ (P = .04)
- 0.43
- Decrease in butyrate vs postoperative CTx, ρ (P = .04)
- −0.43
Observational data: associations, not effects.
Original publication
Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy. J Bone Miner Res. Published 4 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →