Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status
Authors' conclusion
FCA decreases after LSG, with a concurrent rise in bone turnover marker levels and decline in BMD, despite robust 25OHD levels and with recommended calcium intake. Decline in FCA could contribute to negative skeletal effects following LSG.
Study context
- Population
- Women and men with severe obesity undergoing laparoscopic sleeve gastrectomy (LSG), with robust 25OHD levels and recommended calcium intake maintained
- Participants
- 35 women
- Exposure
- Preoperative vs 6 months after LSG
- Outcome
- Intestinal fractional calcium absorption (FCA) by gold-standard dual stable isotope method
- Follow-up
- Preoperatively and 6 months postoperatively
Methodological detailspre-post observational
- Pre-post observational
Main finding
As reported in the abstract
P < 0.01
Observational data: associations, not effects.
Further findings
25OHD level · preoperatively and 6 months postoperatively
Active vitamin D (calcitriol) level · preoperatively and 6 months postoperatively · increased postoperatively
P < 0.01
PTH and 24-hour urinary calcium
- No significant changes in PTH or 24-hour urinary calcium levels
Bone turnover markers
- Bone turnover marker levels increased substantially
Areal bone mineral density (BMD)
- Areal BMD decreased at the proximal femur
Postoperative fractional calcium absorption (FCA) vs areal BMD loss at total hip
- Lower postoperative FCA associated with greater areal BMD loss at total hip, ρ
- 0.45
- P
- P < 0.01
Original publication
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