Circadian variation of serum leptin and adipose tissue changes in children
Authors' conclusion
We found no evidence that circadian variation in serum leptin concentrations during childhood is associated with long-term changes in children's adiposity.
Study context
- Population
- Children (baseline age 9.6 ± 2.5y; 51.1% male; BMI-Z 1.59) with mean follow-up of 11.1 ± 4.0y
- Participants
- 130 children
- Outcome
- Association of leptin circadian variables (acrophase, diurnal amplitude, % change of amplitude) with change in TBFM, %FM and TrFM
- Follow-up
- Mean 11.1 ± 4.0y
Methodological details24-h serum sampling every 3 h, DXA
- 24-h serum sampling every 3 h
- DXA
Main finding
As reported in the abstract
Circadian leptin variables vs change in TBFM, %FM, TrFM
- None of the circadian leptin variables was significantly associated with change in total body fat mass (TBFM), %FM or trunk fat mass (TrFM)
Observational data: associations, not effects.
Further findings
Baseline mesor (24 h average) leptin vs baseline body composition
- TBFM, r2
- 0.78 (p < 0.001)
- %FM, r2
- 076 (p < 0.001)
- TrFM, r2
- 0.71 (p < 0.001)
- Positive associations
Original publication
Circadian variation of serum leptin and adipose tissue changes in children. Pediatr Obes. Published 25 September 2022. doi:10.
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