Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity
Authors' conclusion
Serum leptin was reduced after calorie restriction and this was temporally associated with a reduction in activation of blood CD4 + CD25 + T-Lymphocytes. In abdominal subcutaneous adipose tissue, however, leptin secretion was unaltered, and there were no observed changes in adipose resident T-Lymphocyte activation.
Study context
- Population
- Men with overweight and obesity, age 35–55 years, waist circumference 95–115 cm
- Participants
- 12 men
- Comparison
- After vs before 3 days of 50% calorie restriction
- Calorie restrictionn = 12
- Outcome
- Change after calorie restriction
- Follow-up
- After 3 days
Methodological detailssingle-group, 3-day 50% calorie restriction
- Single-group
- 3-day 50% calorie restriction
Main finding
As reported in the abstract
Serum leptin reduced (mean ± SEM), p < 0.001
31 ± 16%
% blood CD4+CD25+ T-lymphocytes reduced (mean ± SEM), p = 0.016
8 ± 10%
CD25 expression level on blood CD4+CD25+ T-lymphocytes reduced (mean ± SEM), p = 0.058
8 ± 4%
Original publication
Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity. Int J Obes (Lond). Published 27 March 2024. doi:10.
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