Intermittent dietary carbohydrate restriction versus calorie restriction and cardiometabolic profiles: A randomized trial
Authors' conclusion
This study found no evidence of differences in changes from baseline in obesity measures, glucose regulation, and inflammation between ILCD and ICR, despite trends in reduction in those parameters. However, there seemed to be some differences in responses in lipids and gut microbiota.
Study context
- Population
- Participants aged 9 to 30 years with cardiometabolic risk
- Participants
- 34 participants
- Comparison
- Intermittent low-carbohydrate diet vs intermittent calorie restriction
Methodological detailsself-administered, 2-week intervention
- Self-administered
- 2-week intervention
Primary result
As reported in the abstract
Changes in obesity measures, glycemic and lipid profiles and serum biomarkers · 2 weeks
ICR vs ILCDEstimate (95% CI)
Greater increase with ILCD
difference in change in LDL-C −0.36 mmol/L(−0.68 to −0.04)
Greater increase with ILCD
difference in change in total cholesterol −0.40 mmol/L(−0.73 to −0.06)
Greater decrease with ILCD
difference in change in TG 0.20 mmol/L(0.04–0.37)
Further findings
Gut microbiota
- Correlation of reductions with change in fasting glucose (both)
- r = 0.84
- Correlation of reductions with change in LDL-C (Actinobacteria, Bifidobacterium)
- r = −0.81 and −0.72
- Actinobacteria and Bifidobacterium reduced after intermittent low-carbohydrate diet (ILCD) but not ICR
Original publication
Intermittent dietary carbohydrate restriction versus calorie restriction and cardiometabolic profiles: A randomized trial. Obesity (Silver Spring). Published 7 August 2023. doi:10.
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