The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial
Primary result · Change in body weightResult — go to the resultMean difference 2.89 kg 95% CI 5.65–0.14Authors' conclusion
Compared with DCR, 4:3 IMF resulted in modestly greater weight loss among adults with overweight or obesity enrolled in a 12-month, high-intensity, comprehensive behavioral weight loss program.
Study context
- Population
- Adults aged 18–60 years with body mass index (BMI) 27–46 kg/m², Denver, Colorado, and surrounding metropolitan area; mean age 42 years (SD 9), mean BMI 34.1 kg/m² (SD 4.4), 73.9% female125 completed
- Participants
- 165 adults
- Comparison
- 4:3 intermittent fasting (IMF) vs daily caloric restriction (DCR), both with comprehensive behavioral weight loss program
- 4:3 IMFn = 84
- DCRn = 81reference
- Primary endpoint
- Change in body weight (kg)
- Follow-up
- 12 months
Primary result
Change in body weight
Mean difference
2.89 kg
95% CI 5.65–0.14
P = 0.040
As reported in the abstract
Original publication
The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial. Ann Intern Med. Published 1 April 2025. doi:10.
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