Timing of Complementary Feeding in Preterm Infants and Prevalence of Overweight and Obesity: A Randomized Clinical Trial
Authors' conclusion
In this randomized clinical trial of preterm infants, initiating complementary feeding between corrected age 12 and 17 weeks did not affect overweight and obesity prevalence at corrected age 2 years.
Study context
- Population
- Preterm infants born at gestational age (GA) 30–36 weeks, 17 hospitals in the Netherlands; full-term infants as reference255 preterm randomized
- Participants
- 131 / 124 / 159
- Comparison
- Complementary feeding initiated at corrected age 12 weeks vs 17 weeks
- Earlyn = 131
- Laten = 124
- Full-termn = 159reference
- Primary endpoint
- Prevalence of overweight and obesity (logistic mixed models)
- Follow-up
- Corrected age 2 years
Methodological detailsmulticenter, Conducted May 13, 2016 to April 26, 2021; follow-up completed December 2023
- Multicenter
- Conducted May 13, 2016 to April 26, 2021; follow-up completed December 2023
Primary result
As reported in the abstract
Prevalence of overweight
Secondary outcomes
| Outcome | Early | Late | Full-term |
|---|---|---|---|
| Prevalence of obesity (primary outcome component) · corrected age 2 years | 1.7% (95% CI 0.3%–5.5%) | 1.8% (95% CI 0.3%–5.9%) | 3.5% (95% CI 1.3%–7.5%) |
Original publication
Timing of Complementary Feeding in Preterm Infants and Prevalence of Overweight and Obesity: A Randomized Clinical Trial. JAMA Netw Open. Published 1 April 2025. doi:10.
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