Pilot Randomised Trial of Calibrated Formula Volumes to Optimise Growth in Infants at Risk for Overweight: The Califormula Randomised Clinical Trial
Authors' conclusion
Calibrated infant formula recommendations were not associated with growth outcomes.
Study context
- Population
- Exclusively formula fed newborns with birthweight ≥ 50th percentile born to mothers with pre-pregnancy body mass index (BMI) ≥ 25 kg/m²; 36 mothers (66.7%) had pre-pregnancy BMI ≥ 3017 (28.3%) withdrew before 6 months
- Participants
- 60 participants
- Comparison
- Calibrated formula feeding guidance vs usual care
- Primary endpoint
- Conditional weight gain (CWG) between birth and 6 months
- Follow-up
- Birth to 6 months
Methodological detailspilot
- Pilot
Primary result
As reported in the abstract
CWG
Intervention
0.27
mean · 95% CI −0.20–0.75
Usual care
−0.12
mean · 95% CI −0.62–0.37
P = 0.25
Secondary outcomes
Weight-for-length (WFL) z-score and overweight (WFL ≥ 95th percentile) at 6 months, growth trajectory
- No group differences for secondary outcomes
Receipt of calibrated formula guidance
- At each assessment, a minority had WFL ≥ 75th percentile required to receive calibrated formula guidance
Original publication
Pilot Randomised Trial of Calibrated Formula Volumes to Optimise Growth in Infants at Risk for Overweight: The Califormula Randomised Clinical Trial. Pediatr Obes. Published 3 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →