The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity
Authors' conclusion
The lncOb rs10487505 polymorphism affects leptin circulating levels, worsens insulin resistance, and heightens the risk of prediabetes in children and adolescents with obesity.
Study context
- Population
- Children and adolescents with obesityleptin in 150
- Participants
- 434 children
- Exposure
- lncOb rs10487505 CC homozygotes vs G-carriers
- Outcome
- Insulin sensitivity and glucose tolerance
Methodological detailsgenetic association
- Genetic association
Main finding
As reported in the abstract
- CC vs GG/GC: P = 0.01
- CC vs GG/GC: P = 0.01
- CC vs GG/GC: P = 0.02
- CC vs GG/GC: P = 0.03
Observational data: associations, not effects.
Further findings
Prediabetes · prevalence
P = 0.04
| Outcome | Fold higher risk (95% CI) | P value |
|---|---|---|
| PrediabetesIndependent of confounders | 2.9 (1.1–7.9) | P = 0.04 |
- Plasma leptin · lower with CC
- P = 0.002
Correlations of leptin levels
- BMI z score
- r = 0.19, p = 0.04
- Fasting insulin
- r = −0.34, p < 0.0001
- HOMA-IR
- r = −0.33, p < 0.0001
- Disposition index
- r = 0.20, p = 0.04
Original publication
The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity (Silver Spring). Published 7 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →