Who benefits most from outpatient lifestyle intervention? An IMI‐SOPHIA study on pediatric individuals living with overweight and obesity
Authors' conclusion
These results support the importance of patient-tailored intervention and earlier treatment escalation in high-risk individuals who have little chance of success.
Study context
- Population
- Children and adolescents living with overweight/obesity participating in outpatient lifestyle intervention, APV registry; median age 11.5 (IQR 9.7–13.2) years, BMIz 2.06 (IQR 1.79–2.34), 52.6% girls
- Participants
- 12,453 children
- Exposure
- No BMIz loss vs Moderate BMIz loss vs Pronounced BMIz loss
- Outcome
- Distinct subgroups (clusters) of BMIz response
- Follow-up
- Up to 2 years after treatment initiation
Methodological detailslongitudinal k-means clustering, multinomial logistic regression
- Longitudinal k-means clustering
- Multinomial logistic regression
Main finding
As reported in the abstract
BMIz response clusters · study end
| Group | Value | Average delta-BMIz | delta-BMIz up to |
|---|---|---|---|
| No BMIz loss | 36.3% | ||
| Moderate BMIz loss | 44.8% | −0.23 (IQR: −0.33 to −0.14) | |
| Pronounced BMIz loss | 18.9% | −0.61 (IQR: −0.76 to −0.49) |
Value
No BMIz loss36.3%
Moderate BMIz loss44.8%
Pronounced BMIz loss18.9%
Average delta-BMIz
No BMIz loss— not stated in the abstract
Moderate BMIz loss−0.23 (IQR: −0.33 to −0.14)
Pronounced BMIz loss— not stated in the abstract
delta-BMIz up to
No BMIz loss— not stated in the abstract
Moderate BMIz loss— not stated in the abstract
Pronounced BMIz loss−0.61 (IQR: −0.76 to −0.49)
Observational data: associations, not effects.
Further findings
Predictors of moderate or pronounced BMIz loss vs no BMIz loss cluster
- Younger age and lower BMIz at lifestyle intervention (LI) initiation, larger initial BMIz loss and less social deprivation linked with higher likelihood of moderate or pronounced BMIz loss vs no BMIz loss (all p < 0.05)
Original publication
Who benefits most from outpatient lifestyle intervention? An IMI‐SOPHIA study on pediatric individuals living with overweight and obesity. Obesity (Silver Spring). Published 6 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →